LUDIAN, Yunnan, Aug. 4 -- At least 381 people have been killed as of 8:40 a.m. Monday after a 6.5-magnitude earthquake rattled southwest China's Yunnan Province Sunday afternoon, rescuers said.

Chinese Premier Li Keqiang is en route to the quake region to supervise disaster relief work.

The strong quake struck at 4:30 p.m. Sunday (Beijing Time) with a depth of 12 km. The epicenter is in Longtoushan Township, 23 km southwest of the county seat of Ludian.